New N,N,N',N'-tetradentate Pyrazoly Agents: Synthesis and Evaluation of their Antifungal and Antibacterial Activities.
Identifieur interne : 000275 ( Main/Exploration ); précédent : 000274; suivant : 000276New N,N,N',N'-tetradentate Pyrazoly Agents: Synthesis and Evaluation of their Antifungal and Antibacterial Activities.
Auteurs : Farid Abrigach [Maroc] ; Btissam Bouchal ; Olivier Riant ; Yohan Macé ; Abdelilah Takfaoui ; Smaail Radi ; Abdelouahad Oussaid ; Mohammed Bellaoui [Maroc] ; Rachid TouzaniSource :
- Medicinal chemistry (Shariqah (United Arab Emirates)) [ 1875-6638 ] ; 2016.
Descripteurs français
- KwdFr :
- Antibactériens (pharmacologie), Antibactériens (synthèse chimique), Antifongiques (pharmacologie), Antifongiques (synthèse chimique), Diamines (pharmacologie), Diamines (synthèse chimique), Escherichia coli (effets des médicaments et des substances chimiques), Pyrazoles (pharmacologie), Pyrazoles (synthèse chimique), Saccharomyces cerevisiae (effets des médicaments et des substances chimiques), Stéréoisomérie (MeSH).
- MESH :
- effets des médicaments et des substances chimiques : Escherichia coli, Saccharomyces cerevisiae.
- pharmacologie : Antibactériens, Antifongiques, Diamines, Pyrazoles.
- synthèse chimique : Antibactériens, Antifongiques, Diamines, Pyrazoles.
- Stéréoisomérie.
English descriptors
- KwdEn :
- Anti-Bacterial Agents (chemical synthesis), Anti-Bacterial Agents (pharmacology), Antifungal Agents (chemical synthesis), Antifungal Agents (pharmacology), Diamines (chemical synthesis), Diamines (pharmacology), Escherichia coli (drug effects), Pyrazoles (chemical synthesis), Pyrazoles (pharmacology), Saccharomyces cerevisiae (drug effects), Stereoisomerism (MeSH).
- MESH :
- chemical , chemical synthesis : Anti-Bacterial Agents, Antifungal Agents, Diamines, Pyrazoles.
- chemical , pharmacology : Anti-Bacterial Agents, Antifungal Agents, Diamines, Pyrazoles.
- drug effects : Escherichia coli, Saccharomyces cerevisiae.
- Stereoisomerism.
Abstract
A new library of N,N,N',N' -tetradentate pyrazoly compounds containing a pyrazole moiety was synthesized by the condensation of (3,5-dimethyl-1H-pyrazol-1-yl)methanol 2a or (1H-pyrazol-1-yl)methanol 2b with a series of primary diamines in refluxed acetonitrile for 6h. The antifungal activity against the budding yeast Saccharomyces cerevisiae, as well as the antibacterial activity against Escherichia coli of these new tetradentate ligands were studied. We found that these tetradentate ligands act specifically as antifungal agents and lack antibacterial activity. Their biological activities depend on the nature of the structure of the compounds.
DOI: 10.2174/1573406411666150519111800
PubMed: 25985861
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: 000540
- to stream PubMed, to step Curation: 000538
- to stream PubMed, to step Checkpoint: 000474
- to stream Main, to step Merge: 000275
- to stream Main, to step Curation: 000275
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">New N,N,N',N'-tetradentate Pyrazoly Agents: Synthesis and Evaluation of their Antifungal and Antibacterial Activities.</title><author><name sortKey="Abrigach, Farid" sort="Abrigach, Farid" uniqKey="Abrigach F" first="Farid" last="Abrigach">Farid Abrigach</name><affiliation wicri:level="1"><nlm:affiliation>Medical Biology Unit, Faculty of Medicine and Pharmacy of Oujda, University Mohammed the First, Oujda, Morocco. abrigach.farid@live.fr.</nlm:affiliation><country xml:lang="fr">Maroc</country><wicri:regionArea>Medical Biology Unit, Faculty of Medicine and Pharmacy of Oujda, University Mohammed the First, Oujda</wicri:regionArea><wicri:noRegion>Oujda</wicri:noRegion></affiliation></author><author><name sortKey="Bouchal, Btissam" sort="Bouchal, Btissam" uniqKey="Bouchal B" first="Btissam" last="Bouchal">Btissam Bouchal</name></author><author><name sortKey="Riant, Olivier" sort="Riant, Olivier" uniqKey="Riant O" first="Olivier" last="Riant">Olivier Riant</name></author><author><name sortKey="Mace, Yohan" sort="Mace, Yohan" uniqKey="Mace Y" first="Yohan" last="Macé">Yohan Macé</name></author><author><name sortKey="Takfaoui, Abdelilah" sort="Takfaoui, Abdelilah" uniqKey="Takfaoui A" first="Abdelilah" last="Takfaoui">Abdelilah Takfaoui</name></author><author><name sortKey="Radi, Smaail" sort="Radi, Smaail" uniqKey="Radi S" first="Smaail" last="Radi">Smaail Radi</name></author><author><name sortKey="Oussaid, Abdelouahad" sort="Oussaid, Abdelouahad" uniqKey="Oussaid A" first="Abdelouahad" last="Oussaid">Abdelouahad Oussaid</name></author><author><name sortKey="Bellaoui, Mohammed" sort="Bellaoui, Mohammed" uniqKey="Bellaoui M" first="Mohammed" last="Bellaoui">Mohammed Bellaoui</name><affiliation wicri:level="1"><nlm:affiliation>Medical Biology Unit, Faculty of Medicine and Pharmacy of Oujda, University Mohammed the First, Oujda, Morocco. bmbellaoui@gmail.com.</nlm:affiliation><country xml:lang="fr">Maroc</country><wicri:regionArea>Medical Biology Unit, Faculty of Medicine and Pharmacy of Oujda, University Mohammed the First, Oujda</wicri:regionArea><wicri:noRegion>Oujda</wicri:noRegion></affiliation></author><author><name sortKey="Touzani, Rachid" sort="Touzani, Rachid" uniqKey="Touzani R" first="Rachid" last="Touzani">Rachid Touzani</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2016">2016</date><idno type="RBID">pubmed:25985861</idno><idno type="pmid">25985861</idno><idno type="doi">10.2174/1573406411666150519111800</idno><idno type="wicri:Area/PubMed/Corpus">000540</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000540</idno><idno type="wicri:Area/PubMed/Curation">000538</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000538</idno><idno type="wicri:Area/PubMed/Checkpoint">000474</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000474</idno><idno type="wicri:Area/Main/Merge">000275</idno><idno type="wicri:Area/Main/Curation">000275</idno><idno type="wicri:Area/Main/Exploration">000275</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">New N,N,N',N'-tetradentate Pyrazoly Agents: Synthesis and Evaluation of their Antifungal and Antibacterial Activities.</title><author><name sortKey="Abrigach, Farid" sort="Abrigach, Farid" uniqKey="Abrigach F" first="Farid" last="Abrigach">Farid Abrigach</name><affiliation wicri:level="1"><nlm:affiliation>Medical Biology Unit, Faculty of Medicine and Pharmacy of Oujda, University Mohammed the First, Oujda, Morocco. abrigach.farid@live.fr.</nlm:affiliation><country xml:lang="fr">Maroc</country><wicri:regionArea>Medical Biology Unit, Faculty of Medicine and Pharmacy of Oujda, University Mohammed the First, Oujda</wicri:regionArea><wicri:noRegion>Oujda</wicri:noRegion></affiliation></author><author><name sortKey="Bouchal, Btissam" sort="Bouchal, Btissam" uniqKey="Bouchal B" first="Btissam" last="Bouchal">Btissam Bouchal</name></author><author><name sortKey="Riant, Olivier" sort="Riant, Olivier" uniqKey="Riant O" first="Olivier" last="Riant">Olivier Riant</name></author><author><name sortKey="Mace, Yohan" sort="Mace, Yohan" uniqKey="Mace Y" first="Yohan" last="Macé">Yohan Macé</name></author><author><name sortKey="Takfaoui, Abdelilah" sort="Takfaoui, Abdelilah" uniqKey="Takfaoui A" first="Abdelilah" last="Takfaoui">Abdelilah Takfaoui</name></author><author><name sortKey="Radi, Smaail" sort="Radi, Smaail" uniqKey="Radi S" first="Smaail" last="Radi">Smaail Radi</name></author><author><name sortKey="Oussaid, Abdelouahad" sort="Oussaid, Abdelouahad" uniqKey="Oussaid A" first="Abdelouahad" last="Oussaid">Abdelouahad Oussaid</name></author><author><name sortKey="Bellaoui, Mohammed" sort="Bellaoui, Mohammed" uniqKey="Bellaoui M" first="Mohammed" last="Bellaoui">Mohammed Bellaoui</name><affiliation wicri:level="1"><nlm:affiliation>Medical Biology Unit, Faculty of Medicine and Pharmacy of Oujda, University Mohammed the First, Oujda, Morocco. bmbellaoui@gmail.com.</nlm:affiliation><country xml:lang="fr">Maroc</country><wicri:regionArea>Medical Biology Unit, Faculty of Medicine and Pharmacy of Oujda, University Mohammed the First, Oujda</wicri:regionArea><wicri:noRegion>Oujda</wicri:noRegion></affiliation></author><author><name sortKey="Touzani, Rachid" sort="Touzani, Rachid" uniqKey="Touzani R" first="Rachid" last="Touzani">Rachid Touzani</name></author></analytic><series><title level="j">Medicinal chemistry (Shariqah (United Arab Emirates))</title><idno type="eISSN">1875-6638</idno><imprint><date when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Anti-Bacterial Agents (chemical synthesis)</term><term>Anti-Bacterial Agents (pharmacology)</term><term>Antifungal Agents (chemical synthesis)</term><term>Antifungal Agents (pharmacology)</term><term>Diamines (chemical synthesis)</term><term>Diamines (pharmacology)</term><term>Escherichia coli (drug effects)</term><term>Pyrazoles (chemical synthesis)</term><term>Pyrazoles (pharmacology)</term><term>Saccharomyces cerevisiae (drug effects)</term><term>Stereoisomerism (MeSH)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Antibactériens (pharmacologie)</term><term>Antibactériens (synthèse chimique)</term><term>Antifongiques (pharmacologie)</term><term>Antifongiques (synthèse chimique)</term><term>Diamines (pharmacologie)</term><term>Diamines (synthèse chimique)</term><term>Escherichia coli (effets des médicaments et des substances chimiques)</term><term>Pyrazoles (pharmacologie)</term><term>Pyrazoles (synthèse chimique)</term><term>Saccharomyces cerevisiae (effets des médicaments et des substances chimiques)</term><term>Stéréoisomérie (MeSH)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemical synthesis" xml:lang="en"><term>Anti-Bacterial Agents</term><term>Antifungal Agents</term><term>Diamines</term><term>Pyrazoles</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Anti-Bacterial Agents</term><term>Antifungal Agents</term><term>Diamines</term><term>Pyrazoles</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Escherichia coli</term><term>Saccharomyces cerevisiae</term></keywords><keywords scheme="MESH" qualifier="effets des médicaments et des substances chimiques" xml:lang="fr"><term>Escherichia coli</term><term>Saccharomyces cerevisiae</term></keywords><keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Antibactériens</term><term>Antifongiques</term><term>Diamines</term><term>Pyrazoles</term></keywords><keywords scheme="MESH" qualifier="synthèse chimique" xml:lang="fr"><term>Antibactériens</term><term>Antifongiques</term><term>Diamines</term><term>Pyrazoles</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Stereoisomerism</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Stéréoisomérie</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">A new library of N,N,N',N' -tetradentate pyrazoly compounds containing a pyrazole moiety was synthesized by the condensation of (3,5-dimethyl-1H-pyrazol-1-yl)methanol 2a or (1H-pyrazol-1-yl)methanol 2b with a series of primary diamines in refluxed acetonitrile for 6h. The antifungal activity against the budding yeast Saccharomyces cerevisiae, as well as the antibacterial activity against Escherichia coli of these new tetradentate ligands were studied. We found that these tetradentate ligands act specifically as antifungal agents and lack antibacterial activity. Their biological activities depend on the nature of the structure of the compounds. </div></front></TEI><affiliations><list><country><li>Maroc</li></country></list><tree><noCountry><name sortKey="Bouchal, Btissam" sort="Bouchal, Btissam" uniqKey="Bouchal B" first="Btissam" last="Bouchal">Btissam Bouchal</name><name sortKey="Mace, Yohan" sort="Mace, Yohan" uniqKey="Mace Y" first="Yohan" last="Macé">Yohan Macé</name><name sortKey="Oussaid, Abdelouahad" sort="Oussaid, Abdelouahad" uniqKey="Oussaid A" first="Abdelouahad" last="Oussaid">Abdelouahad Oussaid</name><name sortKey="Radi, Smaail" sort="Radi, Smaail" uniqKey="Radi S" first="Smaail" last="Radi">Smaail Radi</name><name sortKey="Riant, Olivier" sort="Riant, Olivier" uniqKey="Riant O" first="Olivier" last="Riant">Olivier Riant</name><name sortKey="Takfaoui, Abdelilah" sort="Takfaoui, Abdelilah" uniqKey="Takfaoui A" first="Abdelilah" last="Takfaoui">Abdelilah Takfaoui</name><name sortKey="Touzani, Rachid" sort="Touzani, Rachid" uniqKey="Touzani R" first="Rachid" last="Touzani">Rachid Touzani</name></noCountry><country name="Maroc"><noRegion><name sortKey="Abrigach, Farid" sort="Abrigach, Farid" uniqKey="Abrigach F" first="Farid" last="Abrigach">Farid Abrigach</name></noRegion><name sortKey="Bellaoui, Mohammed" sort="Bellaoui, Mohammed" uniqKey="Bellaoui M" first="Mohammed" last="Bellaoui">Mohammed Bellaoui</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/MaghrebDataLibMedV2/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000275 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000275 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= MaghrebDataLibMedV2
|flux= Main
|étape= Exploration
|type= RBID
|clé= pubmed:25985861
|texte= New N,N,N',N'-tetradentate Pyrazoly Agents: Synthesis and Evaluation of their Antifungal and Antibacterial Activities.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:25985861" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a MaghrebDataLibMedV2
| This area was generated with Dilib version V0.6.38. |  |